American No.1 Roddick was leading 6-3 2-1 when unseeded with German Kohlschreiber, who was clearly out of the sorts, called it a day.
"We've all been on the bad side of having to pull out of a match. It's not fun," Roddick said.
Chinese wildcard Bai Yan delighted home fans by causing the shock of the day to defeat the world number 30 Radek Stepanek.
Bai, ranked 465 in the world, converted all the four break points he earned to send the Czech star packing 6-3 6-4.
"It's my first time in a top level tournament, so it's really an unexpected performance for me," said 21-year-old.
Fellow home-grown wildcard Zhang Ze gave Croatian Ivan Ljubicic a scare before the Croatian veteran restored order with a 5-7 6-3 6-4 win.
Spain's David Ferrer bounced back from losing the China Open final 24-hours earlier with a 7-6 6-1 win over Frenchman Michael Llodra.
Roddick's compatriot John Isner narrowly avoided an early exit at the hands of Polish qualifier Lukasz Kubot, winning 4-6 7-6 7-6.
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